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Gynecological laparoscopic surgery procedures

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are often complicated by postoperative pain resulting in an unpleasant experience for the patient, delayed discharge, and increased cost. Glucocorticosteroids
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have been suggested to reduce the severity and incidence of postoperative pain. Intraoperative fentanyl
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treatment did not significantly lower the average pain score during the 2 hour postoperative period. This study examines the efficacy of a sustained release betamethasone preparation to reduce postoperative pain and the requirement for pain relief drugs after either diagnostic laparoscopy or tubal ligation. Blood samples
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taken at recovery and at discharge times were extracted and analyzed for circulating betamethasone. The postoperative requirement for pain relief drugs was also examined. It is also well known that
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the serotonergic system is also involved in calcitonin (CT) analgesia. The forced-swimming test was carried out in order to choose doses of each drug that did not induce an antidepressant effect under our experimental conditions (nortriptyline.

At the doses tested,

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the antidepressants induced a dose-dependent analgesic effect. 2.5-20 mg/kg ip, and Paroxetine (
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Paxil ). A randomized, placebo controlled, trial of preoperative sustained release Betamethasone plus non-controlled intraoperative Ketorolac
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or Fentanyl on pain after diagnostic laparoscopy or laparoscopic tubal ligation [ISRCTN52633712].BACKGROUND. Higher pain scores were also observed for the tubal ligation patients relative to diagnostic laparoscopy. Intraoperative ketorolac
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treatment significantly lowered (P 0.027) pain scores and
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reduced the postoperative requirement for additional pain relief drugs. The analgesic effect of each antidepressant was then evaluated using the acetic acid test. Although the injection achieved a sustained therapeutic
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concentration, no beneficial effect of IM betamethasone on postoperative pain or reduction in pain relief drugs was observed during the postoperative period. Prior
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to surgery, patients were randomly selected by a computer generated table to receive either pharmacy-coded betamethasone (12 mg IM Celestone trade mark ) or an optically identical placebo injection of Intralipid trade mark and isotonic saline mixture.

Patients were recruited, as presenting, after obtaining informed consent. There was a lack of efficacy of preoperative

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sustained release betamethasone in reducing postoperative pain despite maintaining a therapeutic concentration during the postoperative period. Sal calcitonin potentiates the analgesia induced ovulation pain relief by are used in the treatment of a variety of pain syndromes. In summary, s-CT was able to increase the analgesic effect of the antidepressant drugs that
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reduce the uptake of 5-HT, suggesting that the joint administration of antidepressants and CT may be an interesting alternative in pain
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management. Taking these two evidences into account, the modification of the analgesic effect of nortriptyline,
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Amitriptyline ( Elavil ), and Paroxetine ( Paxil ) in the presence of sal CT (s-CT) was examined in mice. The effect of non-controlled prophylactic intraoperative treatment with either fentanyl or ketorolac per surgeon's orders
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was also noted in this study.

Intraoperative Ketorolac did afford some short-term pain relief in the postoperative period and reduced the need for additional pain relief drugs.. Most of them act by blocking noradrenaline (NA) and serotonin (5-HT) reuptake.

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When mice were pre-treated with a subanalgesic dose of s-CT (2.5 IU/kg), the analgesic effect of Amitriptyline ( Elavil ) and Paroxetine ( Paxil ) was significantly increased though no modification was found for nortriptyline. Visual analog scale data on pain was gathered at six post-recovery time points in a triple blind fashion and statistically compared. Indeed, the mean combined pain scores during the 2 hour postoperative period, adjusted for postoperative opioids as the major confounding factor, were higher approaching statistical significance (P 0.056) in the treatment group. 0.2-5 mg/kg ip, Amitriptyline ( Elavil ).

 

 

 

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